Selection Technologies & Protein Engineering Co-Op

  • Opportunity Profile:
    • Selection Technologies and Protein Engineering, Co-Op: January 2020 to June 2020
      At Bristol-Myers Squibb, we are a team dedicated to discovering, developing and delivering innovative medicines that help patients prevail over serious diseases. Our commitment is to foster a globally diverse and inclusive workforce with a high-performing culture that is agile, entrepreneurial and accountable.  This enables our business strategy while encouraging excellence, growth, achievement, innovation and a balance between our personal and professional lives. 
      By combining the reach and resources of a global pharmaceutical company with the can-do spirit and agility of a biotechnology company, we are becoming a leader for the future – a next-generation BioPharma leader. 
      For more on BMS Cambridge please watch our video “Cambridge: A Culture of Collaboration” on Youtube
      Six-Month Co-op Opportunity
      Molecular Discovery Technologies (Cambridge, MA)
      This co-op position in the Selection Technologies and Protein Engineering group will involve library-based technologies (e.g. yeast surface display and mRNA display) to engineer and optimize antibodies and other biologic drugs. These in-vitro selection methods involve an element of rational design, to construct trillions of different proteins in a single tube, followed by a series of evolutionary steps mimicking natural selection, in which the molecules with superior properties are selectively amplified. By this process we are able to improve binding affinity while optimizing cross-reactivity, selectivity and manufacturability of our future drugs. Results are analyzed using next-generation sequencing, comparing the behavior of thousands of different proteins under different conditions.
      Enrolled in Bachelor’s degree program in the Sciences.  Desired backgrounds/degrees include (but not limited to):  Biology, Biochemistry, Molecular Biology, Bioengineering, and Chemical Engineering
      Key Learnings:
      • Introduction to discovery of biologics and the role of protein engineering in the design and optimization of novel therapeutics.
      • Understanding of the design and synthesis of libraries containing up to a trillion different proteins
      • Ability to perform molecular biology techniques such as DNA gel electrophoresis, DNA/RNA purification, PCR, mRNA display and yeast surface display
      • Familiarity with analysis of large data sets generated by high throughput sequencing
      Key Deliverables at Project Completion:
      At the end of the co-op period, the student will present their results and conclusions to an audience of Discovery scientists