Selection Technologies & Protein Engineering Co-Op
- Opportunity Profile:
- Selection Technologies and Protein Engineering, Co-Op: January 2020 to June 2020At Bristol-Myers Squibb, we are a team dedicated to discovering, developing and delivering innovative medicines that help patients prevail over serious diseases. Our commitment is to foster a globally diverse and inclusive workforce with a high-performing culture that is agile, entrepreneurial and accountable. This enables our business strategy while encouraging excellence, growth, achievement, innovation and a balance between our personal and professional lives.By combining the reach and resources of a global pharmaceutical company with the can-do spirit and agility of a biotechnology company, we are becoming a leader for the future – a next-generation BioPharma leader.For more on BMS Cambridge please watch our video “Cambridge: A Culture of Collaboration” on Youtube https://www.youtube.com/watch?v=Q9-sF0r4U0USix-Month Co-op OpportunityMolecular Discovery Technologies (Cambridge, MA)This co-op position in the Selection Technologies and Protein Engineering group will involve library-based technologies (e.g. yeast surface display and mRNA display) to engineer and optimize antibodies and other biologic drugs. These in-vitro selection methods involve an element of rational design, to construct trillions of different proteins in a single tube, followed by a series of evolutionary steps mimicking natural selection, in which the molecules with superior properties are selectively amplified. By this process we are able to improve binding affinity while optimizing cross-reactivity, selectivity and manufacturability of our future drugs. Results are analyzed using next-generation sequencing, comparing the behavior of thousands of different proteins under different conditions.Requirements/Education:Enrolled in Bachelor’s degree program in the Sciences. Desired backgrounds/degrees include (but not limited to): Biology, Biochemistry, Molecular Biology, Bioengineering, and Chemical EngineeringKey Learnings:
Key Deliverables at Project Completion:At the end of the co-op period, the student will present their results and conclusions to an audience of Discovery scientists
Introduction to discovery of biologics and the role of protein engineering in the design and optimization of novel therapeutics.
Understanding of the design and synthesis of libraries containing up to a trillion different proteins
Ability to perform molecular biology techniques such as DNA gel electrophoresis, DNA/RNA purification, PCR, mRNA display and yeast surface display
Familiarity with analysis of large data sets generated by high throughput sequencing